Key result
Single-particle image processing reveals considerable myosin flexibility with relative domain movement up to ~12 nm.
Population
Negatively stained myosin molecules
Comparison
Single-particle image processing and… vs Model simulating negative staining of the atomic…
Design
Preclinical
Authors
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Challenges atomic models of myosin; leaves open relevance to human cardiac muscle.
Single-particle image processing of negatively stained myosin reveals significant flexibility between the motor and regulatory domains, challenging the sharply curved conformation seen in atomic models.
Burgess et al. (1997) studied Myosin head structure. Single-particle image processing was evaluated. Single-particle image processing of negatively stained myosin revealed considerable flexibility between the motor and regulatory domains, with relative movement up to 12 nm.
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