Key result
Nasal mucosa stimulation increases pulmonary resistance in dogs but yields unpredictable compliance changes.
Why the study?
Does stimulation of the nasal mucosa affect pulmonary resistance and compliance in awake and anesthetized dogs?
Does stimulation of the nasal mucosa affect pulmonary resistance and compliance in awake and anesthetized dogs?
Stimulation of the nasal mucosa increases pulmonary resistance in both awake and anesthetized dogs, demonstrating a physiologic link between the upper and lower respiratory tracts.
Supports nasopulmonary reflex in dogs; leaves open translation to human respiratory disease.
Changes in pulmonary resistance and compliance, secondary to excitation of a nasopulmonary reflex, were studied in awake and anesthetized dogs. Resistance increased in all dogs after stimulation of the nasal mucosa. Because the direction and magnitude of compliance changes varied widely in both awake and anesthetized dogs, no predictable pattern could be established. A physiologic as well as an anatomic alliance links the upper and lower parts of the respiratory tract. The pathophysiologic significance of this relationship must be determined.
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Whicker et al. (1973) studied this question. Stimulation of the nasal mucosa was evaluated on Changes in pulmonary resistance and compliance. Stimulation of the nasal mucosa increased pulmonary resistance in all awake and anesthetized dogs, while compliance changes varied widely with no predictable pattern.
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