Population
Dogs anesthetized with chloralose, breathing normally with closed chest
Comparison
Inflation of balloons in the pulmonary artery… vs Baseline or different pressure states
Design
Preclinical
Authors
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Supports a novel reflex from lowered pulmonary artery pressure to increased respiration in animals; leaves open clinical relevance in humans.
The study provides quantitative evidence for a previously unreported reflex where lowered pulmonary artery pressure increases respiration rate and depth independently of heart rate.
Kinnison et al. (1965) studied this question.
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