Key result
TPM3 transcripts are expressed in human heart and skeletal muscle alongside dominant TPM1 and TPM2 proteins.
Why the study?
TPM3alpha protein expression in human hearts was not definitively established.
Population
Fetal and adult human hearts, and skeletal muscle samples
Design
Laboratory investigation
Authors
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Novel TPM3 isoforms cloned from human heart; leaves open their functional roles in cardiac cytoskeletal disease.
Dube et al. (2020) studied this question. TPM3 expression was evaluated on TPM3 isoform expression. TPM3 transcripts (TPM3α, TPM3ν, TPM3ξ, TPM3ο) are expressed in human heart and skeletal muscle, with TPM1 being the dominant protein in the heart and TPM2 in skeletal muscle.
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