Key result
Male gender is linked to ~30% higher odds of carotid atherosclerosis versus females.
Why the study?
The study was conducted to assess features of detecting carotid atherosclerosis depending on gender, age, presence of arterial hypertension, and other major diseases and conditions.
Cross-Sectional (n=2,548)
No
Odds Ratio: 1.3 (95% CI 1.13–1.48)
Absolute Event Rate: 58.6% vs 45.5%
p-value: p=0.000008
There are significant gender differences in the prevalence of carotid atherosclerosis and the clinical predictors for its detection, with CAD being more predictive in men and age/hypertension more predictive in women.
May inform sex-specific carotid screening; leaves open longitudinal outcomes and mechanisms.
The aim of this study was to assess the features of detecting carotid atherosclerosis depending on gender, age, the presence of arterial hypertension, other major diseases and conditions according to The Duplex Registry Database. The registry sequentially included the results of duplex scanning of the carotid arteries (DSCA) of all patients who underwent it at the United Hospital with Outpatient Department in 2013 (n=2548). The incidence of carotid atherosclerosis (CAS) was higher in men than in women (58.6% (n=763) vs 45.5% (n=568), p<0.0000001). This was noted in all categories according to the gradation of stenosis, including in the category of the most severe lesion (>70%): 2.9% (n=32) vs 1.0% (n=13), p=0.003. The presence of CAD significantly increased the chances of detecting CAS in men (OR 4.47 vs 2.6, p<0.0000001). Signs more significant in their influence in women compared to men were the following: age (OR 5.3 [4.12; 6.71] p<0.0000001); arterial hypertension (OR 2.7 [2.12; 3.39] p<0.0000001) and cerebrovascular disease (OR 1.63 [1.13; 2.36] p=0.004). The OR of CAS detection for the "acute cerebrovascular accident" diagnosis in men and women differed 2 times (OR 1.2, p=0.4 vs 2.4, p=0.15). The "hypercholesterolemia" diagnosis when referred for DSCA did not show itself as a predictor of CAS detection in all study groups. Disorders of autonomic nervous system, hearing loss and screening examination showed a significant decrease in the probability of CAS detecting for the whole group (OR 0.14 [0.08;0.24] p<0.0000001; OR 0.16 [0.02;0.66] p=0.004 and OR 0.3 [0.25 0.37] p<0.0000001, respectively), so and separately for males and females. The present study revealed significant gender differences in the prevalence of carotid atherosclerosis and in the influence of various signs on an increase in the chances of its detection. The most significant signs were (OR men vs women): gender (1.3 vs 0.8), age (4.2 vs 5.3), arterial hypertension (1.8 vs 2.7), CAD (4.4 vs 2.6), cerebrovascular disease (1.26 vs 1.63).
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Gaisenok et al. (2022) conducted a cross-sectional in Carotid atherosclerosis (n=2,548). Male gender vs. Female gender was evaluated on Detection of carotid atherosclerosis (CAS) (OR 1.3, 95% CI 1.13-1.48, p=0.000008). Male gender was associated with a significantly higher incidence of carotid atherosclerosis compared to female gender (58.6% vs 45.5%, OR 1.3).
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