Key result
Posterior cardiac vein auxiliary shock before primary shock reduces mean DFT energy by ~61%.
Why the study?
Does an auxiliary shock delivered to the left posterior coronary vein before a primary endocardial shock reduce the defibrillation threshold in dogs?
Population
Six pentobarbital-anesthetized dogs (26 to 36 kg)
Comparison
Auxiliary shock applied to the coronary vein… vs Control treatment
Design
Preclinical
Authors
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May reduce defibrillation thresholds in dogs; hypothesis-generating for human ICD configurations, requiring prospective trials.
Does an auxiliary shock delivered to the left posterior coronary vein before a primary endocardial shock reduce the defibrillation threshold in dogs?
Absolute Event Rate: 10.2% vs 26.5%
p-value: p=<0.05
Addition of an auxiliary shock from the posterior cardiac vein before an endocardial primary shock reduces defibrillation threshold energy by more than 50% in a canine model.
KenKnight et al. (2000) studied Ventricular fibrillation (n=6). Auxiliary shock before primary endocardial shock vs. Primary endocardial shock alone was evaluated on Mean defibrillation threshold (DFT) energy (p=<0.05). Addition of an auxiliary shock from the posterior cardiac vein before an endocardial primary shock significantly reduced mean defibrillation threshold energy from 26.5 J to as low as 10.2 J (P<0.05).
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