Key result
D-dimer <275 ng/mL safely excludes PE irrespective of clinical probability.
Why the study?
Does a quantitative latex-agglutination D-dimer assay alone safely exclude pulmonary embolism without the need for clinical risk stratification in patients presenting to emergency departments?
Population
376 patients presenting to emergency departments screened for pulmonary embolism
Comparison
Quantitative latex-agglutination D-dimer assay vs Clinical risk stratification combined with…
Design
Cohort
Authors
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Supports D-dimer <275 ng/mL for ruling out PE in ED patients; leaves open prospective validation before practice change.
Observational (n=376)
Does a quantitative latex-agglutination D-dimer assay alone safely exclude pulmonary embolism without the need for clinical risk stratification in patients presenting to emergency departments?
A quantitative latex-agglutination D-dimer assay with a threshold of <275 ng/mL may safely exclude pulmonary embolism without the need for clinical risk stratification.
Christopher Hammond (2005) conducted an observational in Pulmonary embolism (n=376). Quantitative latex-agglutination D-dimer assay <275 ng/mL was evaluated on Diagnosis of pulmonary embolism. A quantitative latex-agglutination D-dimer assay level of <275 ng/mL excluded pulmonary embolism in all patients (0 cases diagnosed), irrespective of clinical probability.
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