Key result
PC-1 QK genotype links to higher fasting glucose and insulin but not type 2 diabetes.
Why the study?
The association between the PC-1 gene polymorphism c.533A>C (K121Q) and features of the metabolic syndrome, including insulin resistance and type 2 diabetes susceptibility, was unclear.
Does the QK genotype of the PC-1 gene increase features of metabolic syndrome and susceptibility to type 2 diabetes in subjects from Finland and Sweden?
Population
922 subjects from Finland and Sweden including type 2 diabetic patients, control subjects, and relatives
Comparison
QK genotype vs KK genotype of the PC-1 gene
Design
Case-control and intrafamily association studies
Authors
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QK genotype associated with higher glucose/insulin; leaves open PC-1 role in insulin resistance and diabetes risk.
Case-Control (n=922)
Yes
Does the QK genotype of the PC-1 gene increase features of metabolic syndrome and susceptibility to type 2 diabetes in subjects from Finland and Sweden?
Absolute Event Rate: 15.1% vs 12.9%
The Q allele of the human glycoprotein PC-1 gene is associated with surrogate measures of insulin resistance but does not significantly increase susceptibility to type 2 diabetes.
Gu et al. (2000) conducted a case-control in Metabolic syndrome and type 2 diabetes (n=922). Q allele (c.533A>C/K121Q) of the glycoprotein PC-1 gene vs. Non-carriers (KK genotype) or control subjects was evaluated on Q allele frequency. The Q allele of the PC-1 gene was not associated with type 2 diabetes (15.1% vs 12.9%), but the QK genotype was associated with higher fasting plasma glucose and insulin levels (P<0.001).
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