Key result
Bromocriptine decreased mean 24-h recumbent 18-OHB from 23 to 14.3 ng/dl in patients with essential hypertension, without affecting the circadian rhythm of 18-OHB and cortisol.
Why the study?
The influence of bromocriptine on the circadian secretory patterns of plasma 18-hydroxycorticosterone and cortisol in essential hypertension was not well characterized.
Does bromocriptine alter the circadian rhythm of 18-hydroxycorticosterone and cortisol secretion in patients with essential hypertension?
Does bromocriptine alter the circadian rhythm of 18-hydroxycorticosterone and cortisol secretion in patients with essential hypertension?
Absolute Event Rate: 14.3% vs 23%
Bromocriptine decreases the quantitative secretion of 18-OHB but does not alter its circadian rhythm in essential hypertension, suggesting dopaminergic mechanisms affect quantity but not rhythm.
Does not support bromocriptine use in essential hypertension; leaves open dopaminergic effects on 18-OHB quantity versus rhythm.
This study examines the influence of bromocriptine, a dopamine agonist, on circadian secretory patterns of plasma 18-hydroxycorticosterone (18-OHB) and cortisol in essential hypertension. Patients with sustained essential hypertension were studied after they had reached equilibrium on a constant 150 mmol sodium and 80 mmol potassium intake. Plasma 18-OHB and cortisol determinations were made at 30-min intervals over 24 h during a control and bromocriptine treatment period (bromocriptine, 2.5 mg t.i.d. for five days). Circadian patterns for plasma 18-OHB and cortisol were observed in all patients before and after bromocriptine. Although bromocriptine did not affect the circadian rhythm of 18-OHB and cortisol it did decrease mean 24-h recumbent 18-OHB from 23 +/- 42.2 to 14.3 +/- 1.4 ng/dl. These results suggest that there is a circadian rhythm of both 18-OHB and cortisol secretion in patients with essential hypertension as in normotensives. Dopaminergic mechanisms exert an effect on the quantitative secretion of 18-OHB. However, the circadian rhythm for 18-OHB and cortisol does not appear to be dependent on dopaminergic mechanisms.
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Sowers et al. (1983) studied essential hypertension. Bromocriptine vs. Control period was evaluated on mean 24-h recumbent 18-OHB. Bromocriptine decreased mean 24-h recumbent 18-OHB from 23 to 14.3 ng/dl in patients with essential hypertension, without affecting the circadian rhythm of 18-OHB and cortisol.
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