What question did this study set out to answer?

To evaluate the effect of bile salt hydrolase-active Lactobacillus reuteri NCIMB 30242 on gastrointestinal health status based on Rome III questionnaire responses in healthy hypercholesterolemic subjects.

September 28, 2013Expert Opinion on Biological Therapy

Improvement of gastrointestinal health status in subjects consumingLactobacillus reuteriNCIMB 30242 capsules: apost-hocanalysis of a randomized controlled trial

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To evaluate the effect of bile salt hydrolase-active Lactobacillus reuteri NCIMB 30242 on gastrointestinal health status based on Rome III questionnaire responses in healthy hypercholesterolemic subjects.
A post-hoc analysis of a multicenter, randomized, double-blind, placebo-controlled, parallel-arm trial including 127 healthy hypercholesterolemic subjects.
Participants received either Lactobacillus reuteri NCIMB 30242 or placebo capsules over a 9-week intervention period.
Gastrointestinal symptoms were evaluated using the Rome III diagnostic questionnaire (assessing stomach and intestinal symptoms on 5- or 7-point scales) before baseline and at trial endpoint.
Subjects receiving L. reuteri NCIMB 30242 reported significant improvements in general gastrointestinal health status (p = 0.029) and diarrhea-related symptoms (p = 0.018) compared to placebo over 9 weeks.
A significantly greater proportion of L. reuteri-treated subjects achieved improvement in general gastrointestinal health status (p = 0.042) and improvement in diarrhea symptoms (p = 0.03) relative to the placebo arm.

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Implication

Randomized double-blind trial demonstrates improved gastrointestinal status and reduced diarrhea symptoms in hypercholesterolemic adults, suggesting functional benefits of probiotic supplementation.

Cite This Study

Jones et al. (2013) studied this question.

synapsesocial.com/papers/6aa8e126bc25ca06ee299871 https://doi.org/10.1517/14712598.2013.833601

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Implication

Randomized double-blind trial demonstrates improved gastrointestinal status and reduced diarrhea symptoms in hypercholesterolemic adults, suggesting functional benefits of probiotic supplementation.

Improvement of gastrointestinal health status in subjects consumingLactobacillus reuteriNCIMB 30242 capsules: apost-hocanalysis of a randomized controlled trial

Key Points

Discussion

Implication

Cite This Study

Improvement of gastrointestinal health status in subjects consumingLactobacillus reuteriNCIMB 30242 capsules: apost-hocanalysis of a randomized controlled trial

Key Points

Discussion

Implication

Cite This Study

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