What question did this study set out to answer?

To assess the dose-response effects of bile salt hydrolase-active Lactobacillus reuteri NCIMB 30242 on plasma bile acid profiles, FGF-19, and sterol absorption.

January 2, 2015Gut MicrobesOpen Access

Changes in bile acids, FGF-19 and sterol absorption in response to bile salt hydrolase activeL. reuteriNCIMB 30242

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To assess the dose-response effects of bile salt hydrolase-active Lactobacillus reuteri NCIMB 30242 on plasma bile acid profiles, FGF-19, and sterol absorption.
Randomized 10 hypercholesterolemic adults in London, Ontario to receive escalating doses of delayed-release or standard-release L. reuteri NCIMB 30242 capsules over 4 weeks.
Administered constant-dose delayed-release L. reuteri NCIMB 30242 capsules to 4 normocholesterolemic adults (LDL-C < 3.4 mmol/l) over 4 weeks.
Monitored plasma bile acid profiles, circulating FGF-19, plant sterols, LDL cholesterol, fecal microbiota, and bsh gene presence.
Delayed-release L. reuteri increased total bile acids by 1.13 ± 0.67 μmol/l (P = 0.02), conjugated bile acids by 0.67 ± 0.39 μmol/l (P = 0.02), and unconjugated bile acids by 0.46 ± 0.43 μmol/l (P = 0.07) at week 1, exceeding a 2-fold change from baseline.
Elevations in bile acids were largely sustained after week 1, positively correlating with FGF-19 levels and inversely correlating with plant sterols.

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Implication

Randomized trial demonstrates increased circulating bile acids following Lactobacillus reuteri supplementation in adults, indicating rapid modulation of metabolic signaling pathways.

Cite This Study

Martoni et al. (2015) studied this question.

synapsesocial.com/papers/6a0c6cbc106bfae851886b4e https://doi.org/10.1080/19490976.2015.1005474

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Implication

Randomized trial demonstrates increased circulating bile acids following Lactobacillus reuteri supplementation in adults, indicating rapid modulation of metabolic signaling pathways.

Changes in bile acids, FGF-19 and sterol absorption in response to bile salt hydrolase activeL. reuteriNCIMB 30242

Key Points

Discussion

Implication

Cite This Study

Changes in bile acids, FGF-19 and sterol absorption in response to bile salt hydrolase activeL. reuteriNCIMB 30242

Key Points

Discussion

Implication

Cite This Study

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