What type of study is this?

This is a Cohort Study study (also classified as: Animal Study).

September 23, 2025NutrientsOpen Access

Cholesterol-Lowering Mechanism of Lactobacillus Bile Salt Hydrolase Through Regulation of Bifidobacterium pseudolongum in the Gut Microbiota

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This study shows bile salt hydrolase's impact on cholesterol reduction in mice, regulating bifidobacterium pseudolongum and FXR signaling.

Administration of BSH-recombinant strain YB334 reduced serum cholesterol levels in hypercholesterolemic mice.
Serum cholesterol parameters improved significantly, including total cholesterol and low-density lipoprotein levels.
Metagenomic sequencing validated an increased abundance of bifidobacterium pseudolongum in the gut microbiota.
This mechanism suggests modulation of bile acid metabolism via the FXR-CYP7A1 axis may enable effective cholesterol management.

Liu et al. (2025) studied this question.

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This study shows bile salt hydrolase's impact on cholesterol reduction in mice, regulating bifidobacterium pseudolongum and FXR signaling.