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This is a Quantitative Study study (also classified as: In Vitro Study).

October 11, 2025NutrientsOpen Access

Gastrointestinal Survivability of a BSH-Positive Lacticaseibacillus rhamnosus VB4 Strain and Its Effect on Bile Acid Deconjugation in a Dynamic In Vitro Gut Model

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Survivability of the lacticaseibacillus rhamnosus VB4 strain was good during gastrointestinal tract transit.
The strain demonstrated sustained expression of bile salt hydrolase across the stomach and colon fractions.
Bile acid analysis indicated a reduction in conjugated bile acids in the small intestine and improved deconjugation in the colon.
These results highlight the potential of VB4 as a biotherapeutic candidate for bile acid mediation.

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Implication

Analysis reveals the viability of lacticaseibacillus rhamnosus VB4 and its impact on bile acid deconjugation in a dynamic gut model, suggesting its probiotic potential.

Cite This Study

Vaccalluzzo et al. (2025) studied this question.

synapsesocial.com/papers/68e9b1d0ba7d64b6fc132cc8 https://doi.org/10.3390/nu17193179

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Implication

Analysis reveals the viability of lacticaseibacillus rhamnosus VB4 and its impact on bile acid deconjugation in a dynamic gut model, suggesting its probiotic potential.

Gastrointestinal Survivability of a BSH-Positive Lacticaseibacillus rhamnosus VB4 Strain and Its Effect on Bile Acid Deconjugation in a Dynamic In Vitro Gut Model

Key Points

Discussion

Implication

Cite This Study

Gastrointestinal Survivability of a BSH-Positive Lacticaseibacillus rhamnosus VB4 Strain and Its Effect on Bile Acid Deconjugation in a Dynamic In Vitro Gut Model

Key Points

Discussion

Implication

Cite This Study

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