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This is a In Vitro Study study.

September 18, 2025Open Access

Gastrointestinal Survivability of a BSH-Positive Lacticaseibacillus rhamnosus VB4 Strain and Its Effect on Bile Acid Deconjugation in a Dynamic In Vitro Gut Model

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Lacticaseibacillus rhamnosus VB4 shows good survivability in the upper gastrointestinal tract and enhances intestinal health.
The study found the VB4 strain significantly reduced levels of conjugated bile acids during gut passage.
Using the SHIME® model, the research assessed both strain viability and changes in bile acid profiles over time.
These results highlight the potential of strain VB4 as a therapeutic candidate by improving bile acid metabolism.

Authors

AVAmanda VaccalluzzoUniversity of Catania GAGianluigi AgolinoUniversity of Catania APAlessandra PinoUniversity of Catania

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Implication

This in vitro study reveals Lacticaseibacillus rhamnosus VB4 improves bile acid deconjugation in the gastrointestinal tract, indicating its probiotic potential.

Cite This Study

Vaccalluzzo et al. (2025) studied this question.

synapsesocial.com/papers/68d463db31b076d99fa62b40 https://doi.org/10.20944/preprints202509.1391.v1

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Implication

This in vitro study reveals Lacticaseibacillus rhamnosus VB4 improves bile acid deconjugation in the gastrointestinal tract, indicating its probiotic potential.

Gastrointestinal Survivability of a BSH-Positive Lacticaseibacillus rhamnosus VB4 Strain and Its Effect on Bile Acid Deconjugation in a Dynamic In Vitro Gut Model

Key Points

Discussion

Implication

Cite This Study

Gastrointestinal Survivability of a BSH-Positive Lacticaseibacillus rhamnosus VB4 Strain and Its Effect on Bile Acid Deconjugation in a Dynamic In Vitro Gut Model

Key Points

Discussion

Implication

Cite This Study

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