Key result
Patient self-testing with CoaguChek XS yields <1% mean bias compared to professional INR results.
Why the study?
The study aimed to analyze the concordance of INR values obtained by educated lay users with those obtained by professionals and to determine the imprecision of the new CoaguChek XS system.
Does the new CoaguChek XS system provide accurate INR measurements when used by lay patients compared to professionals and the established CoaguChek S system?
Observational (n=75)
Yes
Does the new CoaguChek XS system provide accurate INR measurements when used by lay patients compared to professionals and the established CoaguChek S system?
Effect estimate: mean relative bias <1%
The new CoaguChek XS system provides accurate INR measurements when used by patients, with excellent agreement to professional results and high patient satisfaction.
Supports accuracy for patient self-testing; leaves open outcome benefits versus standard care in trials.
The aim of the study was to analyze the concordance of INR values obtained by educated lay users with those obtained by professionals and to determine the imprecision of the new system. The new CoaguChek XS system was tested in a user study over six weeks at four study centres in Austria, Denmark and Germany. Seventy-five patients receiving oral anticoagulant therapy were enrolled in the study. The INR results in capillary whole blood taken by professionals and by patients using the CoaguChek XS system were similar, and the mean relative bias was <1%. The imprecision of the CoaguChek XS system calculated from duplicate testing is low (<6%) and slightly better than for the established CoaguChek S system. The INR results measured during the home testing phase correlated quite well between the established CoaguChek S system and the new CoaguChek XS system with a mean bias of 0.14 INR. This is a remarkably low bias taking into consideration that more than 30 different test strip lots were applied. A questionnaire was filled out by all patients to assess their personal impression. It revealed that patients were very satisfied with the new system and found it easy to operate. The results demonstrate that the agreement between professional and patient INR results for the new CoaguChek XS system was excellent and that INR values can be determined by lay users as well as by professionals. The instrument is very well accepted by the patients and their satisfaction even increased after four weeks practice at home.
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Watzke et al. (2007) conducted an observational in Patients receiving oral anticoagulant therapy (n=75). CoaguChek XS system vs. Professionals and established CoaguChek S system was evaluated on Concordance of INR values obtained by educated lay users with those obtained by professionals and imprecision of the new system (mean relative bias <1%). The new CoaguChek XS system demonstrated excellent agreement with professional INR results (mean relative bias <1%) and low imprecision (<6%) when used by patients receiving oral anticoagulation.