Key result
Childhood-onset SLE linked to reduced RV global peak longitudinal systolic strain vs healthy volunteers.
Why the study?
Does two-dimensional speckle-tracking echocardiography detect subclinical right ventricle systolic dysfunction in asymptomatic patients with childhood-onset systemic lupus erythematosus compared to healthy volunteers?
Population
35 childhood-onset systemic lupus erythematosus patients with no signs or symptoms of heart failure and 33…
Comparison
Two-dimensional speckle-tracking echocardiography vs Healthy volunteers evaluated by the same…
Design
Case-control
Authors
Loading...
May detect subclinical RV systolic dysfunction by 2DST in asymptomatic c-SLE; hypothesis-generating and requires prospective validation before clinical use.
Case-Control (n=68)
Does two-dimensional speckle-tracking echocardiography detect subclinical right ventricle systolic dysfunction in asymptomatic patients with childhood-onset systemic lupus erythematosus compared to healthy volunteers?
Absolute Event Rate: -24.5% vs -27.62%
p-value: p=0.003
Two-dimensional speckle-tracking echocardiography reveals subclinical right ventricular systolic dysfunction in asymptomatic patients with childhood-onset systemic lupus erythematosus, which is associated with neuropsychiatric manifestations and antiphospholipid antibodies.
Leal et al. (2014) conducted a case-control in Childhood-onset systemic lupus erythematosus (n=68). Childhood-onset systemic lupus erythematosus vs. Healthy volunteers was evaluated on Right ventricle global peak longitudinal systolic strain (PLSS) (p=0.003). Childhood-onset systemic lupus erythematosus was associated with reduced right ventricular global peak longitudinal systolic strain compared to healthy volunteers (-24.5% vs -27.62%; P=0.003).
Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context: