Key result
Pulmonary hypertension in SLE is linked to decreased RV longitudinal systolic strain and strain rate.
Why the study?
Does strain and strain rate imaging detect early right ventricular dysfunction in SLE patients with pulmonary hypertension?
Observational (n=132)
Does strain and strain rate imaging detect early right ventricular dysfunction in SLE patients with pulmonary hypertension?
Strain and strain rate imaging by 2D-STE can detect early right ventricular dysfunction in SLE patients with pulmonary hypertension.
May support strain imaging for subclinical RV dysfunction in SLE-PH; hypothesis-generating and needs longitudinal validation.
BACKGROUND: Right ventricular function is a crucial factor of the prognosis of systemic lupus erythematosus (SLE). OBJECTIVES: To evaluate the right ventricular function in SLE patients with different degrees of pulmonary hypertension (PH) by strain and strain rate imaging. METHODS: A total of 102 SLE patients and 30 healthy volunteers were studied between October 2015 and May 2016. Patients were divided into three groups according to pulmonary artery systolic pressure (PASP) estimated by echocardiography: group control (A); PASP ≤ 30 mmHg (group B, n = 37); PASP 30-50 mmHg (mild PH; group C, n = 34); and PASP ≥ 50 mmHg (moderate-to-severe PH; group D, n = 31). Longitudinal peak systolic strain (ε) and strain rate (SR), including systolic strain rate (SRs), early diastolic strain rate (SRe) and late diastolic strain rate (SRa) were measured in the basal, middle and apical segments of the right ventricular free wall in participants by two-dimensional speckle tracking echocardiography (2D-STE) from the apical four-chamber view. A p < 0.05 was set for statistical significance. RESULTS: The parameters of ε, SRs, SRe, and SRa were significantly decreased in groups C and D compared with groups A and B. The ε of each segments was significantly lower in group D than in group C, while there were no differences in SRs, SRe and SRa between groups C and D. CONCLUSIONS: Strain and strain rate imaging could early detect the right ventricular dysfunction in SLE patients with PH, and provide important value for clinical therapy and prognosis of these patients. (Arq Bras Cardiol. 2018; [online].ahead print, PP.0-0).
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Luo et al. (2018) conducted an observational in Systemic lupus erythematosus (n=132). Pulmonary hypertension vs. Healthy volunteers and SLE patients without pulmonary hypertension was evaluated on Right ventricular function assessed by longitudinal peak systolic strain and strain rate. Mild and moderate-to-severe pulmonary hypertension in SLE patients were associated with significantly decreased right ventricular longitudinal peak systolic strain and strain rate compared to controls.
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