Key result
Asymptomatic females with systemic lupus erythematosus had significantly impaired left ventricular systolic myocardial velocities (medial S' 8.5 vs 9.6 cm/s, P=0.007) compared to healthy controls.
Why the study?
Routine echocardiography often misses early myocardial involvement in systemic lupus erythematosus, prompting the use of TDI and strain imaging to detect subclinical myocardial dysfunction and its link to disease activity.
Does tissue Doppler and strain imaging detect subclinical myocardial dysfunction in asymptomatic female patients with SLE compared to healthy controls?
Comparison
Asymptomatic female SLE patients vs matched healthy controls
Design
Case-control study
Authors
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Hypothesis-generating for subclinical LV dysfunction in asymptomatic SLE; leaves open need for prospective validation before screening.
Case-Control (n=63)
Does tissue Doppler and strain imaging detect subclinical myocardial dysfunction in asymptomatic female patients with SLE compared to healthy controls?
Absolute Event Rate: 8.5% vs 9.6%
p-value: p=0.007
Tissue Doppler and strain imaging can detect early subclinical left ventricular systolic dysfunction in asymptomatic patients with SLE, which correlates with disease activity.
Harsha et al. (2020) conducted a case-control in Systemic lupus erythematosus (n=63). Systemic lupus erythematosus vs. Healthy controls was evaluated on Systolic myocardial velocity of left ventricle (medial S') (p=0.007). Asymptomatic females with systemic lupus erythematosus had significantly impaired left ventricular systolic myocardial velocities (medial S' 8.5 vs 9.6 cm/s, P=0.007) compared to healthy controls.
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