Key result
Antiphospholipid syndrome in SLE is linked to ~91% higher frequency of mitral regurgitation.
Why the study?
Echocardiographic changes in SLE patients with and without APS and their relation to disease activity and damage were not well characterized.
Population
50 SLE patients (25 with APS and 25 without) and 50 controls
Comparison
SLE patients with APS vs without APS
Design
Observational study using transthoracic echocardiography
Authors
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May warrant valvular monitoring in SLE with APS; leaves open causal mechanisms and therapeutic impact.
Observational (n=100)
Absolute Event Rate: 84% vs 44%
Rady et al. (2017) conducted an observational in Systemic lupus erythematosus (n=100). Antiphospholipid syndrome (APS) vs. SLE without APS was evaluated on Mitral regurgitation. SLE patients with antiphospholipid syndrome had a higher frequency of mitral (84% vs 44%), aortic (32% vs 12%), and tricuspid (36% vs 12%) regurgitation compared to those without.
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