Key result
Asymptomatic SLE is linked to early cardiac dysfunction versus controls, evidenced by higher E/E' ratio.
Why the study?
Does transthoracic Doppler echocardiography identify early cardiac dysfunction in asymptomatic patients with systemic lupus erythematosus compared to controls?
Population
80 patients: 50 asymptomatic systemic lupus erythematosus patients and 30 controls. SLE patients were…
Comparison
Transthoracic Doppler echocardiographic imaging vs Healthy control group (n=30)
Design
Case-control
Authors
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TTE may detect subclinical dysfunction in asymptomatic SLE; leaves open whether routine screening alters outcomes.
Observational (n=80)
Does transthoracic Doppler echocardiography identify early cardiac dysfunction in asymptomatic patients with systemic lupus erythematosus compared to controls?
p-value: p=<0.01
Transthoracic Doppler echocardiography can identify early subclinical cardiac dysfunction in asymptomatic SLE patients, which is more pronounced in those with anticardiolipin antibodies or higher disease activity.
Barutçu et al. (2015) conducted an observational in Systemic lupus erythematosus (n=80). Systemic lupus erythematosus vs. Healthy controls was evaluated on Ratio of mitral peak velocity of early filling to early diastolic mitral annular velocity (E/E') (p=<0.01). Asymptomatic systemic lupus erythematosus was associated with early cardiac dysfunction compared to controls, evidenced by a higher E/E' ratio and greater left atrial dimension (p<0.01).
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