Key result
Org 7797 mimics propafenone in porcine tissue as a class 1c sodium channel blocker.
Why the study?
The electrophysiologic effects of the new class I steroidal antiarrhythmic agent Org 7797 were evaluated to characterize its action compared to established class I agents.
Does Org 7797 exhibit specific class I antiarrhythmic electrophysiologic properties in porcine ventricular and Purkinje tissue?
Population
Porcine ventricular and Purkinje tissue
Comparison
Org 7797 vs propafenone, lignocaine, and disopyramide
Design
In vitro electrophysiologic study using conventional microelectrode techniques
Authors
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Does not support clinical use; leaves open human efficacy and safety trials for this class Ic candidate.
Does Org 7797 exhibit specific class I antiarrhythmic electrophysiologic properties in porcine ventricular and Purkinje tissue?
Absolute Event Rate: 0.074% vs 0.078%
In vitro electrophysiologic testing demonstrates that the new steroidal antiarrhythmic agent Org 7797 functions as a class 1c agent.
Winslow et al. (1989) studied this question. Org 7797 vs. propafenone, lignocaine, and disopyramide was evaluated on rate constant of sodium channel block at 1.0 Hz. Org 7797 demonstrated slow sodium channel block kinetics (rate constant 0.074) and electrophysiologic effects similar to propafenone in porcine tissue, characterizing it as a class 1c agent.
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