Population
Anaesthetized dogs with 5-6 day-old left ventricular myocardial infarcts
Comparison
Intravenous Org 7797 (0.5 mg/kg and 2 mg/kg) vs Intravenous disopyramide, mexiletine, and…
Design
Preclinical
Authors
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Does not support clinical use; leaves open translation of its class Ic-like profile to human arrhythmia trials.
In a canine model of myocardial infarction, the novel agent Org 7797 demonstrated electrophysiological properties characteristic of class Ic antiarrhythmic drugs.
Campbell et al. (1991) studied this question.
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