Why the study?
Does Org 7797 alter electrophysiological parameters in closed-chest anaesthetized dogs and guinea-pig papillary muscle?
Population
Closed-chest anaesthetized dogs with normal cardiac function, and guinea-pig isolated papillary muscle
Design
Preclinical
Authors
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Hypothesis-generating for AF rate control; leaves open translation from this animal model to clinical use.
Does Org 7797 alter electrophysiological parameters in closed-chest anaesthetized dogs and guinea-pig papillary muscle?
Org 7797 exhibits preferential action on the AV node at lower doses, which may help control ventricular rate during atrial fibrillation, while higher doses display a Class Ic profile.
Leboeuf et al. (1993) studied this question.
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