Key result
Org 7797 prevents ~100% of VF in regionally ischemic pig hearts versus control.
Why the study?
Org 7797 is effective against ventricular fibrillation induced during ischemia, but its mechanism of antifibrillatory action in ischemic myocardium was unclear.
Does Org 7797 prevent ventricular fibrillation in regionally ischemic pig hearts?
Population
Langendorff-perfused pig hearts with regional ischemia induced by coronary occlusion
Comparison
Org 7797 (2-10 microM) vs absence of drug
Design
Preclinical experimental study
Authors
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Org 7797 merits further preclinical study; leaves open translation to human VF prevention.
Does Org 7797 prevent ventricular fibrillation in regionally ischemic pig hearts?
Absolute Event Rate: 0% vs 100%
Org 7797 prevents ischemia-induced ventricular fibrillation in a pig heart model by prolonging the refractory period and wavelength at very short cycle lengths.
Janse et al. (1990) studied Ventricular fibrillation during ischemia. Org 7797 vs. Absence of drug was evaluated on Induction of ventricular fibrillation (VF). Org 7797 (2-10 microM) completely prevented the induction of ventricular fibrillation in regionally ischemic pig hearts, whereas VF was always induced in the absence of the drug.
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