Why the study?
Does Org 7797 reduce ischemia-induced arrhythmias compared to flecainide and propafenone in rat and dog models of coronary artery occlusion?
Population
Rats and dogs (greyhounds and beagles) with coronary artery occlusion (early, late, and inducible arrhythmias)
Comparison
Org 7797 (0.5-2.0 mg kg-1 intravenous) vs Flecainide and propafenone
Design
Preclinical
Authors
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Should not yet change practice for ischemia-induced VF; leaves open translation of Org 7797 potency to human coronary occlusion models.
Does Org 7797 reduce ischemia-induced arrhythmias compared to flecainide and propafenone in rat and dog models of coronary artery occlusion?
Org 7797 is a potent, hemodynamically well-tolerated antifibrillatory agent in preclinical models of ischemia-induced arrhythmias, showing greater potency than flecainide and propafenone.
Winslow et al. (1991) studied this question.
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