Key result
Childhood and adolescent obesity drives high triglycerides and low HDL-C, leading to early cardiovascular injury.
Pediatric obesity drives an atherogenic lipid profile characterized by high triglycerides and low HDL-C, which correlates with early subclinical cardiovascular injury and warrants early comprehensive screening and intervention.
Key messageChildren and adolescents with obesity commonly develop atherogenic dyslipidemia characterized by elevated triglyceride, reduced high-density lipoprotein cholesterol (HDL-C), and elevated non-HDL-C levels, and increased triglyceride/ HDL-C ratio.This pattern worsens with obesity severity and clusters with insulin resistance, hypertension, vascular dysfunction, and cardiac remodeling.Early comprehensive screening and structured family-centered intervention are essential for reducing long-term cardiovascular risk.
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Soliman et al. (2026) conducted a review in Childhood and adolescent obesity. Obesity vs. Normal weight was evaluated. Childhood and adolescent obesity consistently drives an atherogenic lipid profile characterized by elevated triglycerides and reduced HDL-C, which worsens with obesity severity and leads to early cardiovascular injury.
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