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September 15, 2026European Heart Journal Supplements

Ring–like Lge in Non–dilated Left Ventricular Cardiomyopathy: Imaging–genetic Integration for Early Arrhythmic Risk Stratification

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Key result

Integrating CMR and genetics guides early extravascular ICD implantation in non-dilated LV cardiomyopathy.

  • n=1

Population

One 46-year-old woman with chest pain, palpitations, and family history of LMNA-related dilated cardiomyopathy

Design

Case report

Authors

AFA FerroSCS CrispinoMCM Ciancio

Discussion

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Overview

May guide early ICD decisions via CMR-genetic integration in non-dilated cardiomyopathy; extends guidelines but remains hypothesis-generating.

Key Points

  • To describe how integrating cardiac magnetic resonance tissue characterization with genetic risk factors identifies high arrhythmic risk in non-dilated left ventricular cardiomyopathy.
  • Evaluated a 46-year-old female presenting with chest pain, palpitations, and a family history of LMNA-related dilated cardiomyopathy.
  • Performed continuous electrocardiographic monitoring, transthoracic echocardiography, coronary CT angiography, and cardiac magnetic resonance imaging.
  • Transthoracic echocardiography showed a preserved left ventricular ejection fraction of 60%, yet ECG monitoring recorded frequent non-sustained ventricular tachycardia.
  • Cardiac MRI revealed a ring-like pattern of late gadolinium enhancement consistent with diffuse myocardial fibrosis, prompting primary prevention extravascular ICD implantation.

Study Design

Type

Case Report (n=1)

Structured PICO

P
Population
A 46-year-old woman with non-dilated left ventricular cardiomyopathy and a family history of LMNA mutation-related cardiomyopathy.
I
Intervention
Extravascular implantable cardioverter-defibrillator (ICD) implantation for primary prevention.

Integrating CMR tissue characterization (ring-like LGE) with genetic context and family history can guide early arrhythmic risk stratification and ICD implantation in non-dilated left ventricular cardiomyopathy.

Cite This Study

Ferro et al. (2026) conducted a case report in Non-dilated left ventricular cardiomyopathy (NDLVC) (n=1). Extravascular ICD implantation guided by CMR and genetics was evaluated. In a 46-year-old woman with non-dilated left ventricular cardiomyopathy, integrating CMR tissue characterization (ring-like LGE) and genetic context guided early extravascular ICD implantation.

synapsesocial.com/papers/6aa9017deed42882c1fc18cdhttps://doi.org/10.1093/eurheartjsupp/suag058.230
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Arrhythmic risk prediction in non-dilated left ventricular cardiomyopathy: The role of overlap with arrhythmogenic cardiomyopathy2025 · 12 citations
  2. 2FROM ELECTRICAL DISEASE TO STRUCTURAL CARDIOMYOPATHY: A CHALLENGIES IN RISK STRATIFICATION IN ASYMPTOMATIC LMNA VARIANT CARRIERS2026
  3. 3Integrated Role of Cardiac Magnetic Resonance and Genetics in Predicting Left Ventricular Reverse Remodelling in Dilated and Non-Dilated Cardiomyopathy2025 · 19 citations
  4. 4Clinical Characteristics and Outcomes of Patients With Biventricular and Left-Dominant Arrhythmogenic Cardiomyopathy With Ring-like Late Gadolinium Enhancement Pattern2026 · 2 citations
  5. 5Late gadolinium enhancement distribution patterns in non-ischaemic dilated cardiomyopathy: genotype–phenotype correlation2023 · 66 citations