What is the clinical evidence from this study?

Study design: Cohort. Population: Mitral valve surgery (n=797). Intervention: NT-proBNP levels. Primary outcome: 90-day mortality (OR 1.674, 95% CI 1.230-2.277).

What question did this study set out to answer?

To evaluate the association between NT-proBNP levels and 90-day mortality and perioperative complications in patients undergoing mitral valve surgery.

September 15, 2026European Heart Journal Supplements

Nt–probnp as Predictor of Mortality in Patients Undergoing Mitral Valve Surgery

Q: What does this research mean for the field?

Pre-operative NT-proBNP levels are an independent predictor of 90-day mortality and adverse peri-operative outcomes in patients undergoing mitral valve surgery. Novelty: ClaimNovelty.CONFIRMATORY. Consensus alignment: ConsensusAlignment.NEUTRAL.

View Full Paper

Ask AI

Bookmark

Key result

Elevated NT-proBNP predicts ~67% higher 90-day mortality after mitral valve surgery.

OR 1.674
95% CI 1.230-2.277
n=797

Why the study?

Evidence regarding the prognostic role of NT-proBNP in patients with valvular heart disease, particularly those undergoing cardiac surgery, remains limited.

Does pre-operative NT-proBNP level predict 90-day mortality and peri-operative outcomes in patients undergoing mitral valve surgery?

Key Points

To evaluate the association between NT-proBNP levels and 90-day mortality and perioperative complications in patients undergoing mitral valve surgery.
Analyzed an observational cohort of 797 patients (mean age 67 years; 45.3% female; 17.2% prior cardiac surgery) undergoing mitral valve surgery between 2020 and 2025.
Measured log-transformed NT-proBNP before surgery, at day 5, at 3 months, and during follow-up, evaluating discrimination via ROC curves and Youden index.
Identified risk factors for 90-day mortality, post-operative complications, and hospital length of stay using univariate and stepwise multivariable logistic regression.
Overall 90-day mortality was 3.5%, in-hospital mortality was 1.6%, acute kidney injury occurred in 7.0%, low cardiac output syndrome in 1.8%, and stroke in 1.3%.
In multivariable analysis, log NT-proBNP remained an independent predictor of 90-day mortality (OR 1.674, 95% CI 1.230–2.277), along with age (OR 1.080, 95% CI 1.020–1.143) and cardiopulmonary bypass time (OR 1.016, 95% CI 1.008–1.025).
ROC analysis established an optimal log NT-proBNP cutoff of 6.99 for discriminating 90-day mortality and 6.86 for an ICU length of stay exceeding 24 hours.

Study Design

Type

Cohort (n=797)

Structured PICO

Does pre-operative NT-proBNP level predict 90-day mortality and peri-operative outcomes in patients undergoing mitral valve surgery?

Population

797 patients (mean age 67 years, 45.3% female) undergoing mitral valve surgery, evaluated for 90-day mortality and peri-operative outcomes.

Exposure

Pre-operative NT-proBNP measurement

Outcome

Prognostic value of NT-proBNP on 90-day mortalityhard clinical

Main Result

Odds Ratio: 1.674 (95% CI 1.23–2.277)

Pre-operative NT-proBNP is an independent predictor of 90-day mortality and peri-operative outcomes in patients undergoing mitral valve surgery, supporting its use in pre-operative risk stratification.

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

May support preoperative risk stratification in mitral valve surgery; extends HF data but leaves open prospective validation.

Cite This Study

Aloi et al. (2026) conducted a cohort in Mitral valve surgery (n=797). NT-proBNP levels was evaluated on 90-day mortality (OR 1.674, 95% CI 1.230-2.277). Elevated NT-proBNP levels independently predicted 90-day mortality in patients undergoing mitral valve surgery (OR 1.674; 95% CI 1.230-2.277).

synapsesocial.com/papers/6aa9017deed42882c1fc1972 https://doi.org/10.1093/eurheartjsupp/suag058.017

Topics

Heart failure HFrEF treatment

View Full Paper

Ask AI

Bookmark

Nt–probnp as Predictor of Mortality in Patients Undergoing Mitral Valve Surgery

Key Points

Study Design

Structured PICO

Main Result

Discussion

Implication

Cite This Study

Topics

Nt–probnp as Predictor of Mortality in Patients Undergoing Mitral Valve Surgery

Key Points

Study Design

Structured PICO

Main Result

Discussion

Implication

Cite This Study

Also Consider

Topics

Also Consider