Key result
Salvianolic acid B lowers fasting glucose and improves lipid profiles versus control in rodents.
Why the study?
The study aimed to estimate the effect of salvianolic acid B on glycometabolism and lipid metabolism in rats and mice.
Does salvianolic acid B improve glycometabolism and lipid metabolism in rodents?
Meta-Analysis (n=547)
Does salvianolic acid B improve glycometabolism and lipid metabolism in rodents?
Salvianolic acid B improves glycometabolism and lipid metabolism in rodent models, suggesting potential as a therapeutic agent for metabolic diseases such as diabetes and hyperlipidemia.
Supports rodent metabolic benefits; extends meta-analytic preclinical data but leaves human translation open.
Danshen (Salvia miltiorrhiza) is a herb which has been widely used in China. Salvianolic acid B (SalB) is an aqueous bioactive component derived from Danshen. Here, we aimed to estimate the effect of SalB on glycometabolism and lipid metabolism in rats and mice. We searched four databases until November 2020. The outcome measures were fasting blood glucose (FBG), total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDLc), and low-density lipoprotein cholesterol (LDLc). Twenty-four studies involving 547 animals were included. The meta-analysis showed effects of SalB on decreasing the level of FBG, TC, TG, LDLc, and increasing the level of HDLc compared with the control group. In conclusion, the result showed that SalB may regulate the glycometabolism and lipid metabolism in rats or mice, and may be a potential agent for treating metabolic diseases such as diabetes and hyperlipidemia.
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Lv et al. (2020) conducted a meta-analysis in Glycometabolism and lipid metabolism (n=547). Salvianolic acid B (SalB) vs. control group was evaluated on Fasting blood glucose (FBG), total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDLc), and low-density lipoprotein cholesterol (LDLc). Salvianolic acid B decreased fasting blood glucose, total cholesterol, triglycerides, and LDLc, and increased HDLc compared with the control group in rats and mice.
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