Key result
24-hour BNP levels independently predict 1-year mortality in acute decompensated heart failure.
Why the study?
Natriuretic peptide variations during hospitalisation in acute decompensated heart failure patients appear useful to predict short-term and long-term outcomes.
Does the reduction of BNP and NT-proBNP from admission to discharge predict future cardiovascular events in patients with acute decompensated heart failure?
Does the reduction of BNP and NT-proBNP from admission to discharge predict future cardiovascular events in patients with acute decompensated heart failure?
Reduction of BNP and NT-proBNP levels during hospitalization for acute decompensated heart failure is a useful predictor of future cardiovascular events.
Acute decompensated heart failure is one of the most important causes of hospitalisation worldwide. Natriuretic peptides have shown their usefulness in the diagnosis and management of heart failure. Their variations during hospitalisation also appear useful to predict outcomes. In particular, data from the literature demonstrate that reduction from admission to discharge of brain natriuretic peptide and N-terminal prohormone brain natriuretic peptide in these patients is a predictor of future cardiovascular events.
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Somma et al. (2011) conducted an editorial in acute decompensated heart failure. Brain natriuretic peptide (BNP) at 24 hours was evaluated on 1-year mortality (1.02, 95% CI 1.01 to 1.04, p=0.003). In patients with acute decompensated heart failure, BNP levels at 24 hours independently predicted 1-year mortality.
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