Key result
Intraperitoneal G-4260 picornavirus inoculation lowers 7-day mean body weight in chicks versus controls.
Why the study?
The pathogenicity of the G-4260 strain of picornavirus for day-old chicks was studied to understand its effects and organ distribution.
Intraperitoneal inoculation of day-old chicks with the G-4260 strain of avian nephritis virus causes reduced body weight and renal infection without overt clinical signs.
Answers are grounded in this paper and cite their sources.
Indicates possible subclinical growth effects in chicks; leaves open implications for avian health and further research.
The pathogenicity of the G-4260 strain of picornavirus for day-old chicks was studied by intraperitoneal inoculation. No clinical signs were observed. A mild yellowish-tan discoloration of the kidneys was noticed in necropsy 7 to 21 days after inoculation. Mean body weight was significantly lower (P less than 0.01) in inoculated groups than in control groups 7 days after inoculation. In a chronological study on the distribution of the virus in organs, the virus was recovered from various organs, exclusive of the brain and trachea. The virus titer was higher in the kidneys, jejunum, rectum, and bursa of Fabricius than in any other organ. Fluorescent antigens were seen predominantly in the epithelia of the renal tubules.
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Imada et al. (1979) studied Avian Nephritis Virus infection. G-4260 strain of picornavirus vs. Control groups was evaluated on Mean body weight (p=<0.01). Intraperitoneal inoculation of day-old chicks with the G-4260 strain of picornavirus resulted in lower mean body weight at 7 days compared to controls.
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