Key result
Type 1 diabetes is linked to higher activated protein C sensitivity ratios versus healthy controls.
Why the study?
The anticoagulant response to activated protein C in patients with insulin-dependent diabetes mellitus and its relationship with coagulation factors was not well characterized.
Is the anticoagulant response to activated protein C altered in patients with insulin-dependent diabetes mellitus compared to healthy subjects?
Population
67 patients with IDDM and 40 healthy subjects
Comparison
Patients with IDDM vs healthy subjects
Design
Observational study using modified activated thromboplastin time assay
Authors
Loading...
Heightened APC sensitivity in IDDM warrants no practice change; leaves open its role in diabetes-related coagulopathy.
Observational (n=107)
Is the anticoagulant response to activated protein C altered in patients with insulin-dependent diabetes mellitus compared to healthy subjects?
p-value: p=<0.001
Patients with IDDM exhibit an enhanced anticoagulant response to activated protein C compared to healthy subjects, indicating a complex role in regulating the coagulation system.
Krugluger et al. (1995) conducted an observational in Insulin-dependent diabetes mellitus (IDDM) (n=107). Insulin-dependent diabetes mellitus (IDDM) vs. Healthy subjects was evaluated on APC sensitivity ratio (APC SR) (p=<0.001). Patients with insulin-dependent diabetes mellitus had a significantly higher median APC sensitivity ratio (2.5 to 2.7) compared to healthy control subjects (2.1, P<0.001).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: