Key result
A 1-U decrease in response to activated protein C was associated with an increased risk of carotid stenosis (OR 1.6; 95% CI 1.2-2.2), femoral artery stenosis, and prevalent cardiovascular disease.
Why the study?
Does poor response to activated protein C predict advanced atherosclerosis and arterial disease in the general population?
Population
826 men and women from a random sample in a population-based survey
Comparison
Poor response to activated protein C vs Normal or higher response to activated protein C
Design
Cross-sectional
Authors
Loading...
May support APC resistance as atherosclerosis biomarker; leaves open prospective validation before clinical use.
Cross-Sectional (n=826)
Does poor response to activated protein C predict advanced atherosclerosis and arterial disease in the general population?
Effect estimate: OR 1.6 (95% CI 1.2-2.2)
Poor response to activated protein C is independently associated with advanced atherosclerosis and prevalent cardiovascular disease, regardless of factor V Leiden mutation status.
Kiechl et al. (1999) conducted a cross-sectional in Atherosclerosis and arterial disease (n=826). Decreasing response to activated protein C (APC) was evaluated on Carotid stenosis (OR 1.6, 95% CI 1.2-2.2). A 1-U decrease in response to activated protein C was associated with an increased risk of carotid stenosis (OR 1.6; 95% CI 1.2-2.2), femoral artery stenosis, and prevalent cardiovascular disease.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: