What is the clinical evidence from this study?

Study design: Observational. Population: Essential hypertension and diabetes mellitus (n=235). Intervention: Lipoprotein(a). Primary outcome: Correlation of Lp(a) with blood lipids, coagulation, and fibrinolysis parameters.

What question did this study set out to answer?

To determine whether circulating lipoprotein(a) levels correlate with standard lipid profiles, coagulation factors, and fibrinolysis markers in patients with hypertension or diabetes.

June 1, 1992Blood Coagulation & Fibrinolysis

Low order correlations of lipoprotein(a) with other blood lipids and with coagulation and fibrinolysis parameters in hypertensive and diabetic patients

Q: What does this research mean for the field?

Lipoprotein(a) levels correlate modestly with LDL-cholesterol but are not associated with coagulation or fibrinolysis parameters in hypertensive or diabetic patients. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

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Key result

Lp(a) correlates with LDL-C in hypertensive and diabetic patients but not with coagulation or fibrinolysis.

n=235

Population

235 patients, comprising 54 with essential hypertension, 65 with non-insulin-dependent diabetes, and 116…

Design

Cross-sectional

Authors

SDS. H. J. DondersRadboud University Nijmegen FLF. A. Th. LustermansMaastricht University JWJ. W. J. van WerschDe Wever-Ziekenhuis

Discussion

Member takes

Implication

Lp(a)-LDL correlation without coagulation links in hypertension or diabetes; leaves open alternative risk pathways and needs prospective mechanistic studies.

Key Points

To determine whether circulating lipoprotein(a) levels correlate with standard lipid profiles, coagulation factors, and fibrinolysis markers in patients with hypertension or diabetes.
Measured lipid profiles, coagulation markers (fibrinogen, factor VII, factor VIII:C, fibrin monomers, thrombin-antithrombin III), and fibrinolytic markers (t-PA antigen, PAI-1, D-dimer).
Analyzed biomarker correlations across 54 patients with essential hypertension, 65 patients with non-insulin-dependent diabetes, and 116 patients with insulin-regulated diabetes.
Lipoprotein(a) correlated significantly with LDL-cholesterol (r = 0.25, P = 0.04) and triglycerides (r = -0.30, P = 0.03) in hypertension, and with LDL-cholesterol in insulin-regulated diabetes (r = 0.20, P = 0.03).
No significant correlations occurred between lipoprotein(a) and any coagulation or fibrinolysis parameters across any patient cohort, despite evidence of activated baseline coagulation.

Study Design

Type

Observational (n=235)

Structured PICO

Population

235 patients comprising 54 with essential hypertension, 65 with non-insulin-dependent diabetes, and 116 with insulin-regulated diabetes.

Outcome

Correlations between Lipoprotein(a) and other blood lipids, coagulation parameters, and fibrinolysis parameterssurrogate

Lipoprotein(a) levels do not correlate with coagulation or fibrinolysis parameters in hypertensive or diabetic patients, suggesting its cardiovascular risk mechanism may not be directly mediated through these pathways in these populations.

Cite This Study

Donders et al. (1992) conducted an observational in Essential hypertension and diabetes mellitus (n=235). Lipoprotein(a) was evaluated on Correlation of Lp(a) with blood lipids, coagulation, and fibrinolysis parameters. Lipoprotein(a) correlated with LDL-cholesterol in hypertensive (r=0.25, P=0.04) and insulin-regulated diabetic patients (r=0.20, P=0.03), but not with coagulation or fibrinolysis parameters.

synapsesocial.com/papers/6aa9115bda99bfa923299d85 https://doi.org/10.1097/00001721-199206000-00003

Topics

Hypertension management

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Implication

Lp(a)-LDL correlation without coagulation links in hypertension or diabetes; leaves open alternative risk pathways and needs prospective mechanistic studies.

Low order correlations of lipoprotein(a) with other blood lipids and with coagulation and fibrinolysis parameters in hypertensive and diabetic patients

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Cite This Study

Topics

Low order correlations of lipoprotein(a) with other blood lipids and with coagulation and fibrinolysis parameters in hypertensive and diabetic patients

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider