What is the clinical evidence from this study?

Study design: Cross-Sectional. Population: acute gastroenteritis (n=2754). Intervention: Rotavirus A infection. Primary outcome: Rotavirus A (RVA) positivity.

What does this research mean for the field?

Among pediatric acute gastroenteritis cases in Thailand, rotavirus A infections were predominantly caused by G1P[8] (56.5%) alongside an unusually high prevalence of G8P[8] strains (20.0%), with both displaying atypical short RNA electropherotypes. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

August 24, 2016Journal of Medical Virology

Predominant prevalence of human rotaviruses with the G1P8 and G8P8 genotypes with a short RNA profile in 2013 and 2014 in Sukhothai and Phetchaboon provinces, Thailand

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Key result

Rotavirus A is detected in ~24% of pediatric acute gastroenteritis, predominantly the G1P8 and G8P8 strains.

n=2,754

Population

2,754 stool specimens collected from children with acute gastroenteritis during 2013-2014 in Sukhothai and…

Design

Cross-sectional

Authors

RGRatigorn GuntapongNational Institute of Health of Thailand RTRatana TacharoenmuangNational Institute of Health of Thailand PSPhakapun SingchaiNational Institute of Health of Thailand

Discussion

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Implication

Rotavirus A prevalence with unusual G8P[8] strains warrants ongoing surveillance; leaves open vaccine coverage implications in Southeast Asia.

Study Design

Type

Cross-Sectional (n=2,754)

Multicenter

Yes

Structured PICO

Population

2,754 stool specimens collected from children with acute gastroenteritis during 2013-2014 in two provinces of Thailand.

Outcome

Prevalence of rotavirus A (RVA) and its G and P genotypes

The study highlights a high prevalence of unusual G8P[8] human rotaviruses and a short RNA pattern in G1P[8] strains in Thailand during 2013-2014.

Cite This Study

Guntapong et al. (2016) conducted a cross-sectional in acute gastroenteritis (n=2,754). Rotavirus A infection was evaluated on Rotavirus A (RVA) positivity. Among children with acute gastroenteritis, 24.2% of stool specimens were positive for rotavirus A, predominantly the G1P[8] (56.5%) and unusual G8P[8] (20.0%) genotypes.

synapsesocial.com/papers/6aa91377b7876cb3302c8e7a https://doi.org/10.1002/jmv.24669

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Implication

Rotavirus A prevalence with unusual G8P[8] strains warrants ongoing surveillance; leaves open vaccine coverage implications in Southeast Asia.

Predominant prevalence of human rotaviruses with the G1P8 and G8P8 genotypes with a short RNA profile in 2013 and 2014 in Sukhothai and Phetchaboon provinces, Thailand

Discussion

Member takes

Implication

Study Design

Structured PICO

Cite This Study

Predominant prevalence of human rotaviruses with the G1P8 and G8P8 genotypes with a short RNA profile in 2013 and 2014 in Sukhothai and Phetchaboon provinces, Thailand

Discussion

Member takes

Implication

Study Design

Structured PICO

Cite This Study

Also Consider

Also Consider