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October 31, 2014Arteriosclerosis Thrombosis and Vascular BiologyOpen Access

Protein Kinase C δ Deficiency Enhances Megakaryopoiesis and Recovery From Thrombocytopenia

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Key result

PKCδ deficiency in mice increases white blood cells and platelets, accelerating recovery from thrombocytopenia.

  • P<0.05

Why the study?

Does Protein Kinase C δ (PKCδ) deficiency enhance megakaryopoiesis and recovery from thrombocytopenia in mice?

Population

PKCδ(-/-) and wild-type littermate mice

Comparison

Protein Kinase C δ deficiency vs Wild-type littermate mice

Design

Preclinical

Authors

JKJohn C. KostyakThomas Jefferson UniversityDBDheeraj BhavanasiUniversity of PennsylvaniaELElisabeta Liverani

Discussion

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Implication

May support PKCδ as a thrombocytopenia target in mice; leaves open human translation and should not change practice.

Structured PICO

Does Protein Kinase C δ (PKCδ) deficiency enhance megakaryopoiesis and recovery from thrombocytopenia in mice?

P
Population
PKCδ(-/-) and wild-type littermate mice evaluated for megakaryopoiesis and recovery from thrombocytopenia.
E
Exposure
Protein Kinase C δ (PKCδ) deficiency (genetic knockout)
C
Comparator
Wild-type littermate mice
O
Outcome
White blood cell and platelet counts, and bone marrow and splenic megakaryocytessurrogate

Main Result

p-value: p=<0.05

PKCδ deficiency enhances megakaryopoiesis and accelerates recovery from thrombocytopenia, suggesting PKCδ as a potential therapeutic target for thrombocytopenia.

Cite This Study

Kostyak et al. (2014) studied Thrombocytopenia. PKCδ deficiency vs. Wild-type littermate mice was evaluated on White blood cell and platelet counts, bone marrow and splenic megakaryocytes (p=<0.05). PKCδ deficiency in mice caused an increase in white blood cells, platelet counts, and megakaryocytes (P<0.05), and led to faster recovery from thrombocytopenic challenge compared with wild-type.

synapsesocial.com/papers/6aa9230107f6ffa79a0c030chttps://doi.org/10.1161/atvbaha.114.304492
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Thrombopoietin, the Mp1 ligand, is essential for full megakaryocyte development.1995 · 329 citations
  2. 2Purification and Characterization of Thrombopoietin11995 · 249 citations
  3. 3Thrombopoietin-Induced Activation of the Mitogen-Activated Protein Kinase (MAPK) Pathway in Normal Megakaryocytes: Role in Endomitosis1999 · 214 citations
  4. 4Inhibition of protein kinase C suppresses megakaryocytic differentiation and stimulates erythroid differentiation in HEL cells1996 · 70 citations
  5. 5The inositol phosphatase SHIP-1 is negatively regulated by Fli-1 and its loss accelerates leukemogenesis2010 · 61 citations