Key result
PKC modulation of L-type calcium channels regulates trigger calcium for calcium-induced signaling in cardiac muscle.
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May guide PKC-targeted arrhythmia therapies; leaves open clinical translation from basic calcium signaling.
L-type calcium channel (LTCC) function is critical for electrical and cellular signaling in a diverse range of cell types. In cardiac muscle LTCC function (ICa,L) provides trigger Ca2+ for Ca2+-ind...
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Jonathan Satin (2013) studied this question. Protein kinase C modulation of the L-type calcium channel regulates trigger calcium for calcium-induced signaling in cardiac muscle.
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