Key result
SLCO1B1 *1a/*15 and ApoE ε3/ε3 link to lower CHD risk while ApoE ε4 marks higher risk.
Why the study?
This study aimed to analyze the influence of SLCO1B1 and APOE gene polymorphisms on coronary heart disease in the Mongolian population living in the Ordos area.
Do SLCO1B1 and ApoE gene polymorphisms affect the risk of coronary heart disease in the Mongolian population?
Population
200 Mongolian patients with coronary heart disease and 150 healthy Mongolian controls in Ordos area
Comparison
Patients with coronary heart disease vs healthy controls
Design
Case-control study
Authors
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May refine ethnicity-specific CHD risk models in Mongolians; hypothesis-generating and requires validation before clinical use.
Case-Control (n=350)
Yes
Do SLCO1B1 and ApoE gene polymorphisms affect the risk of coronary heart disease in the Mongolian population?
p-value: p=<.05
In the Mongolian population, the SLCO1B1 *1a/*15 and ApoE ε3/ε3 genotypes are protective against coronary heart disease, whereas the ApoE ε4 allele increases the risk.
Niu et al. (2021) conducted a case-control in Coronary heart disease (n=350). SLCO1B1 and ApoE gene polymorphisms vs. Reference genotypes was evaluated on Coronary heart disease (p=<.05). SLCO1B1 *1a/*15 and ApoE ε3/ε3 genotypes were associated with reduced risk of coronary heart disease in the Mongolian population, whereas the ApoE ε4 allele increased the risk (P<.05).
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