Key result
Carvedilol suppresses AF inducibility and oxidative stress in a canine model without altering heart rate.
Why the study?
Does carvedilol reduce atrial fibrillation inducibility and oxidative stress in a canine model of atrial fibrillation?
Does carvedilol reduce atrial fibrillation inducibility and oxidative stress in a canine model of atrial fibrillation?
Absolute Event Rate: 155% vs 177%
p-value: p=0.08
Carvedilol suppresses atrial fibrillation inducibility and oxidative stress in a canine model of rapid atrial pacing.
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May attenuate AF inducibility in canines; leaves open translation to human AF prevention.
Kishihara et al. (2014) studied Atrial fibrillation (n=15). Carvedilol vs. Pacing control was evaluated on Heart rate (p=0.08). Carvedilol suppressed AF inducibility and oxidative stress in a canine model, with no significant difference in heart rate compared to pacing control (155 vs 177 bpm, P=0.08).
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