What question did this study set out to answer?

Provide clinical guidance on the diagnostic challenges, biomarker evaluations, and therapeutic strategies for hemophagocytic lymphohistiocytosis in the intensive care unit.

June 2, 2026World Journal of Critical Care MedicineOpen Access

Hemophagocytic lymphohistiocytosis in critically ill patients: A guide for clinicians

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Provide clinical guidance on the diagnostic challenges, biomarker evaluations, and therapeutic strategies for hemophagocytic lymphohistiocytosis in the intensive care unit.
Synthesized diagnostic frameworks including the HLH-2004 criteria and HScore alongside clinical presentations in adult critical care.
Assessed management strategies combining causal trigger management with immunomodulatory regimens, including corticosteroids, intravenous immunoglobulin, anakinra, and etoposide.
Distinguishing secondary hemophagocytic lymphohistiocytosis from sepsis is hindered by overlapping clinical features like persistent fevers and cytopenias, as well as hyperferritinemia that lacks isolated specificity.
Intensive care unit mortality remains substantial, especially among patients requiring invasive organ support, emphasizing the necessity of early multidisciplinary intervention.

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Implication

Clinical review details diagnostic challenges and immunosuppressive therapies in critically ill adults with hemophagocytic lymphohistiocytosis, highlighting the need for prompt recognition.

Cite This Study

Wagner Nedel (2026) studied this question.

synapsesocial.com/papers/6aa931bbbd00adaa8902c686 https://doi.org/10.5492/wjccm.120840

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Implication

Clinical review details diagnostic challenges and immunosuppressive therapies in critically ill adults with hemophagocytic lymphohistiocytosis, highlighting the need for prompt recognition.

Hemophagocytic lymphohistiocytosis in critically ill patients: A guide for clinicians

Key Points

Discussion

Implication

Cite This Study

Hemophagocytic lymphohistiocytosis in critically ill patients: A guide for clinicians

Key Points

Discussion

Implication

Cite This Study

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