Key result
Myoglobin assays show limited clinical utility for ACS or rhabdomyolysis, prompting their discontinuation.
Why the study?
Medical laboratories advise physicians on relevant biological test usage to avoid redundant ordering or useless tests, prompting an evaluation of the clinical utility of myoglobin assays.
Does the myoglobin assay provide useful diagnostic or prognostic information in patients with acute coronary syndromes or rhabdomyolysis?
Does the myoglobin assay provide useful diagnostic or prognostic information in patients with acute coronary syndromes or rhabdomyolysis?
Routine myoglobin testing has limited clinical utility and is no longer recommended for the management of acute coronary syndromes or rhabdomyolysis.
Answers are grounded in this paper and cite their sources.
May support de-implementation of myoglobin assays; leaves open prospective outcome studies in the high-sensitivity troponin era.
The clinical biologist plays a role as a consultant for the relevant use of biological examination. Advisory activities of the medical laboratory may help physician in diagnosis or therapeutic algorithm, avoiding redundant ordering or useless tests. In this context, we performed a review of literature about the clinically interest of myoglobin assays. The indications of myoglobin's assays appear fairly limited. It is no longer mentioned in the European guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation. In patients with rhabdomyolysis myoglobin is neither a diagnostic nor a prognostic criterion. Its interest in predicting the occurrence of acute renal failure is also discussed. The most recent clinico-biological score (such as the McMahon score) do not integrate it. In this context, we decided to stop performing myoglobin assay.
No takes yet. Share an insight, caveat, or question.
Servonnet et al. (2018) conducted a review in Acute coronary syndromes, rhabdomyolysis, acute renal failure. Myoglobin assay was evaluated on Clinical utility of myoglobin assays. A literature review indicates that myoglobin assays have limited clinical utility for acute coronary syndromes or rhabdomyolysis, leading to the decision to stop performing the assay.
Synapse has enriched 10 related papers. Consider them for comparative context: