Key result
CMD affects men and women with HFpEF equally but involves distinct proteomic drivers.
Why the study?
Little information is available regarding sex differences in coronary microvascular dysfunction among patients with HFpEF.
Do proteomic correlates of coronary microvascular dysfunction differ by sex in patients with HFpEF?
Observational (n=182)
Yes
Do proteomic correlates of coronary microvascular dysfunction differ by sex in patients with HFpEF?
Absolute Event Rate: 77% vs 70%
p-value: p=0.27
While the prevalence of coronary microvascular dysfunction is similar between sexes in HFpEF, the underlying pathophysiological drivers may differ, with inflammation predominating in men and ventricular remodeling/fibrosis in women.
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Sex-specific proteomic correlates of CMD in HFpEF may aid phenotyping; leaves open targeted therapies pending prospective validation.
Chandramouli et al. (2022) conducted an observational in Heart failure with preserved ejection fraction (HFpEF) (n=182). Male sex vs. Female sex was evaluated on Prevalence of coronary microvascular dysfunction (CMD) (p=0.27). The prevalence of coronary microvascular dysfunction was similarly high in men and women with HFpEF (77% vs. 70%; p=0.27), but the proteomic drivers differed by sex.
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