Key result
Higher pulse pressure linked to ~94% greater CKD risk per SD in type 2 diabetes.
Why the study?
Identification of factors associated with risk of progression of chronic kidney disease may help in earlier intervention in high-risk groups, including those with type 2 diabetes.
Does higher brachial pulse pressure increase the risk of eGFR decline and incident CKD in individuals with and without type 2 diabetes?
Population
5554 individuals without CKD or microalbuminuria at baseline from the AusDiab study, 5.8% with type 2 diabetes
Comparison
Higher brachial pulse pressure vs lower brachial pulse pressure
Design
Population-based cohort study
Follow-up
5 years
Authors
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Pulse pressure may flag elevated CKD risk in diabetes; leaves open whether targeting it alters progression.
Cohort (n=5,554)
Does higher brachial pulse pressure increase the risk of eGFR decline and incident CKD in individuals with and without type 2 diabetes?
Odds Ratio: 1.94 (95% CI 1.14–3.29)
Higher pulse pressure is a significant risk factor for eGFR decline and incident CKD over 5 years, with the risk being substantially amplified in patients with type 2 diabetes.
Hurk et al. (2011) conducted a cohort in Chronic kidney disease (n=5,554). Higher brachial pulse pressure vs. Lower brachial pulse pressure was evaluated on Incident CKD (OR 1.94, 95% CI 1.14-3.29). Each standard deviation increase in baseline pulse pressure was associated with incident chronic kidney disease over 5 years, with a stronger effect in type 2 diabetes (OR 1.94; 95% CI 1.14-3.29).
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