Key result
Central obesity linked to ~20% higher oxidative stress versus peripheral obesity.
Why the study?
Data supporting oxidant-antioxidant disturbance differences between centrally and peripherally obese subjects were lacking.
Does central body fat distribution correlate with higher oxidative stress compared to peripheral obesity and normal weight?
RCT (n=400)
randomised
No
Does central body fat distribution correlate with higher oxidative stress compared to peripheral obesity and normal weight?
Central fat deposition in obesity is associated with significantly higher oxidative stress compared to peripheral obesity, highlighting a potential mechanism for increased cardiovascular risk in centrally obese individuals.
May signal higher cardiovascular risk in central obesity; leaves open causal pathways and intervention targets.
BACKGROUND , there are experimental and clinical evidences on oxidant-antioxidant disturbance in obese patients, data supporting same in centrally and peripherally obese subjects is lacking. aim of the study is to study the effect of body fat distribution on oxidative stress parameters in obesity. AND METHODS prospective randomised study was done on 300 obese subjects and compared with 100 normal subjects having BMI between 19 to 25 kg/m2 the Department of Medicine and Department of Biochemistry, G. R. Medical College, Gwalior. Patients were as case (n=300) and control (n=100). Detailed physical examination and laboratory investigation including Fasting Glucose (FBG) and complete lipid profile was done and recorded for each subject. The waist and hip was measured with tape to calculate the waist/hip ratio. Patients were divided on the basis of central and peripheral obesity. Superoxide (SOD) activity and plasma Malondialdehyde (MDA) level were also estimated. age in case and control group was 46.2 ± 2.4 years and 44.5 ± 2.2 years (p>0.05) respectively with male predominance. of subjects were centrally obese (82.33%) in centrally obese patients MDA levels (4.89 ± 1.26 vs. 4.06 ± 1.12 μmol/mL) higher and SOD levels (8.62 ± 2.23 vs. 9.58 ± 1.26 units/mL) were lower compared to peripheral obesity (p<0.001). (P<0.001) difference was observed for MDA level between case and control in centrally obese (4.89 ± 1.26 vs. 2.06 ± 0.76, respectively) and peripherally obese (4.06 ± 1.12 vs. 2.06 ± 0.76, respectively) subjects. Similarly, SOD level between and control among centrally obese (8.62 ± 2.23 vs. 12.42 ± 2.18) and peripherally obese (9.58 ± 1.26 vs. 12.42 ± 2.18) was significantly different (P<0.001). central fat deposition in abdomen or the apple-shaped obesity is associated with higher oxidative stress in obese subjects.
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Agrawal et al. (2017) conducted an RCT in Obesity (n=400). Central obesity vs. Peripheral obesity was evaluated on Plasma Malondialdehyde (MDA) level (p=<0.001). Central obesity was associated with significantly higher oxidative stress than peripheral obesity, indicated by higher plasma MDA levels (4.89 vs. 4.06 μmol/mL; P<0.001).
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