Key result
CTO PCI linked to a ~1.3% absolute improvement in day-one GLS.
Why the study?
The feasibility of using two-dimensional speckle tracking echocardiography to monitor left ventricular function after percutaneous recanalization of chronic coronary occlusions was evaluated.
Does primary PCI improve left ventricular function assessed by 2D-STE and conventional echocardiography in patients with coronary chronic total occlusion?
Observational (n=43)
No
Does primary PCI improve left ventricular function assessed by 2D-STE and conventional echocardiography in patients with coronary chronic total occlusion?
Absolute Event Rate: -14.54% vs -13.25%
p-value: p=<0.001
2D-STE can detect early improvements in left ventricular function (GLS) as early as 1 day after CTO-PCI, before changes in LVEF become apparent.
PCI for CTO was associated with rapid GLS improvement; hypothesis-generating for clinical benefit pending randomized confirmation.
BACKGROUND: This study evaluated the feasibility of using two-dimensional speckle tracking echocardiography (2D-STE) to monitor left ventricular (LV) and overall function after percutaneous recanalization. METHODS: LV function after percutaneous recanalization was monitored by 2D-STE and conventional echocardiography in 43 patients with coronary chronic total occlusion (CTO) who underwent primary percutaneous coronary intervention (PCI). Follow-ups were carried out 1 day as well as 3 and 6 months after CTO-PCI. At each time point, LV ejection fraction (LVEF) was examined by echocardiography, and LV global longitudinal strain (GLS) was measured by 2D-STE. RESULTS: It was found that the global longitudinal strain assessed with 2D-STE was improved as early as 1 day after CTO-PCI, whereas LVEF tended to improve up to 3 and 6 months after CTO-PCI. CONCLUSION: PCI can effectively improve LV function in patients with CTO. 2D-STE is a superior technique for objectively quantifying the functional change earlier.
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Wang et al. (2018) conducted an observational in Chronic total occlusion (CTO) (n=43). Percutaneous coronary intervention (PCI) vs. Preoperative baseline was evaluated on Global longitudinal strain (GLS) at 1 day post-PCI (p=<0.001). Percutaneous coronary intervention for chronic total occlusion significantly improved global longitudinal strain as early as 1 day post-procedure (from -13.25 to -14.54, p<0.001).
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