Metabolic syndrome, organ damage and cardiovascular disease in treated hypertensive patients. The ERIC‐HTA study
Key result
Metabolic syndrome in non-diabetic hypertensives is linked to ~22% higher prevalence of established CVD.
- OR 1.22
- 95% CI 1.08-1.37
- P=0.001
- n=8,331
Why the study?
Is metabolic syndrome associated with target organ damage and established cardiovascular disease in non-diabetic hypertensive elderly patients?
Population
8,331 non-diabetic hypertensive patients aged 55 or older in primary care.
Comparison
Presence of metabolic syndrome vs Absence of metabolic syndrome
Design
Cross-sectional
Authors
Discussion
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Member takes
Implication
Does not support practice change in non-diabetic hypertensives; leaves open metabolic syndrome's role in target organ damage among the elderly.
Study Design
Type
Cross-Sectional (n=8,331)
Multicenter
Yes
Structured PICO
Is metabolic syndrome associated with target organ damage and established cardiovascular disease in non-diabetic hypertensive elderly patients?
P
Population
8,331 non-diabetic hypertensive patients aged 55 or older evaluated in primary care.
E
Exposure
Presence of metabolic syndrome (defined by NCEP-ATP III criteria using BMI >28.8 kg/m2 instead of abdominal perimeter)
C
Comparator
Absence of metabolic syndrome
O
Outcome
Prevalence of left ventricle hypertrophy (LVH) on electrocardiogram, impaired kidney function, and established cardiovascular disease (CVD)
Main Result
Odds Ratio: 1.22 (95% CI 1.08–1.37)
p-value: p=0.001
In elderly non-diabetic hypertensive patients, metabolic syndrome is independently associated with a higher prevalence of target organ damage and established cardiovascular disease.
Cite This Study
Navarro et al. (2007) conducted a cross-sectional in Non-diabetic hypertension (n=8,331). Metabolic syndrome vs. No metabolic syndrome was evaluated on Established cardiovascular disease (OR 1.22, 95% CI 1.08-1.37, p=0.001). Metabolic syndrome in non-diabetic hypertensive patients was associated with a greater prevalence of established cardiovascular disease (OR 1.22; 95% CI 1.08-1.37).