Key result
Nonalcoholic fatty liver disease linked to higher vWF and TFPI levels versus controls.
Why the study?
Cardiovascular risk factors are common in NAFLD patients, but the presence of endothelial injury and changes in coagulation parameters in NAFLD were not well characterized.
Are levels of endothelium-derived coagulation parameters altered in patients with nonalcoholic fatty liver disease compared to controls?
Case-Control
Are levels of endothelium-derived coagulation parameters altered in patients with nonalcoholic fatty liver disease compared to controls?
Answers are grounded in this paper and cite their sources.
NAFLD is associated with increased levels of vWF and TFPI, suggesting the presence of endothelial injury that may contribute to cardiovascular risk.
In a majority of patients with nonalcoholic fatty liver disease (NAFLD), cardiovascular risk factors including diabetes mellitus type 2, abdominal obesity, and metabolic syndrome are present. The purpose of this study is to investigate the presence of endothelial injury and the changes in coagulation parameters in NAFLD patients. For this purpose, plasma levels of von Willebrand factor (vWF), thrombomodulin, urokinase plasminogen activator (uPA), plasminogen activator inhibitor-1 (PAI-1), and tissue factor pathway inhibitor (TFPI) in patients with NAFLD were measured. There was a significant difference in vWF and TFPI levels between patient and control groups (P < 0.05). However, no statistically significant difference was obtained in PAI-1, uPA, and thrombomodulin levels between the two groups (P > 0.05). According to our results, an increase in vWF and TFPI levels indicates an endothelial injury in NAFLD cases.
No takes yet. Share an insight, caveat, or question.
Bilgir et al. (2013) conducted a case-control in Nonalcoholic fatty liver disease (NAFLD). Nonalcoholic fatty liver disease vs. Control group was evaluated on Plasma levels of von Willebrand factor (vWF), thrombomodulin, uPA, PAI-1, and TFPI (p=<0.05). Nonalcoholic fatty liver disease was associated with higher levels of von Willebrand factor and tissue factor pathway inhibitor compared to controls.
Synapse has enriched 10 related papers. Consider them for comparative context: