Key result
Cytosine arabinoside, cyclophosphamide, and total body irradiation linked to fatal cardiac toxicity in three transplant patients.
Why the study?
Fatal cardiac toxicity associated with the combination of cytosine arabinoside, cyclophosphamide, and total body irradiation in bone marrow transplant preparation was not previously characterized.
Case Report (n=3)
The combination of cytosine arabinoside, cyclophosphamide, and total body irradiation for bone marrow transplant preparation can cause fatal cardiac toxicity, which might be averted by lowering the cyclophosphamide dose.
Answers are grounded in this paper and cite their sources.
Raises caution for fatal cardiotoxicity with this BMT regimen; leaves open whether dose modification reduces risk.
Three patients developed fatal cardiac toxicity from the combination of cytosine arabinoside, cyclophosphamide, and total body irradiation while undergoing preparation for a bone marrow transplant. The pattern of the toxicity was unique for this combination of ablative chemotherapy. All three patients had autopsies demonstrating characteristic myocardial and pericardial toxicity. The cardiotoxic effects of this combination may be averted by lowering the dose of the cyclophosphamide.
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Trigg et al. (1987) conducted a case report in Bone marrow transplant preparation (n=3). Cytosine arabinoside, cyclophosphamide, and total body irradiation was evaluated on Fatal cardiac toxicity. The combination of cytosine arabinoside, cyclophosphamide, and total body irradiation resulted in fatal cardiac toxicity in three bone marrow transplant patients.
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