Key result
Furosemide linked to lower cardiac output and blood pressure at 60 minutes in pre-eclampsia.
Why the study?
Does furosemide reduce blood pressure and cardiac output in patients with late-onset pre-eclampsia and high cardiac output?
Cohort (n=14)
No
Does furosemide reduce blood pressure and cardiac output in patients with late-onset pre-eclampsia and high cardiac output?
A single 40-mg dose of furosemide acutely reduces blood pressure and cardiac output in patients with late-onset pre-eclampsia and high cardiac output.
Answers are grounded in this paper and cite their sources.
Should not yet change practice in late-onset pre-eclampsia; leaves open need for RCTs on maternal-fetal outcomes.
OBJECTIVE: To examine the effect of furosemide on hypertension and edema in patients with pre-eclampsia experiencing high cardiac output. METHODS: The present cohort study enrolled patients with pre-eclampsia who were admitted to the pregnancy pathology unit of the Department of Obstetrics and Gynecology, University of Pécs, Hungary, between January 1 and December 31, 2015. Eligible patients had singleton pregnancies with no fetal anomalies, high blood volume, visible edema, and a hematocrit concentration below 37 L/L. Blood pressure was measured and impedance cardiography was used to determine cardiac output for all patients before they received a 40-mg dose of furosemide; after 60 minutes blood pressure and cardiac output were measured again. RESULTS: The study enrolled 14 patients. Lower cardiac output (P=0.002), systolic blood pressure (P=0.002), and diastolic blood pressure (P=0.002) were recorded after furosemide administration, with patient heart rates remaining stable. CONCLUSION: The heart-rate stability suggests that the change of cardiac output was due to a decrease in blood volume. These data suggest that diuretics could be useful in the management of late-onset pre-eclampsia, indicating that an increase in water retention could play a role in the development of late-onset pre-eclampsia.
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Tamás et al. (2016) conducted a cohort in late-onset pre-eclampsia with high cardiac output (n=14). furosemide vs. baseline (before administration) was evaluated on cardiac output, systolic blood pressure, and diastolic blood pressure (p=0.002). Furosemide administration lowered cardiac output, systolic blood pressure, and diastolic blood pressure at 60 minutes in patients with pre-eclampsia.
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