Incidence and outcomes of infective endocarditis after transcatheter aortic valve implantation versus surgical aortic valve replacement
Key result
TAVI is linked to similar IE risk as SAVR but higher mortality if infected.
- RR 1.09
- 95% CI 0.96-1.23
- n=107,806
Why the study?
Data on the incidence, risk factors, and outcomes of infective endocarditis following TAVI versus surgical AVR have been conflicting.
Does TAVI compared to SAVR affect the incidence and mortality of infective endocarditis in patients with aortic stenosis?
Comparison
Percutaneous TAVI vs isolated SAVR
Design
Nationwide retrospective database cohort study
Follow-up
Median 1.2 years
Authors
Discussion
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Member takes
Implication
Warrants heightened vigilance for mortality if endocarditis occurs post-TAVI; extends observational data but leaves open randomized confirmation.
Study Design
Type
Cohort (n=107,806)
Multicenter
Yes
Structured PICO
Does TAVI compared to SAVR affect the incidence and mortality of infective endocarditis in patients with aortic stenosis?
P
Population
107,806 patients with aortic stenosis treated with TAVI or isolated SAVR in France between 2010 and 2018, followed for a mean of 2.0 years.
E
Exposure
Transcatheter aortic valve implantation (TAVI)
C
Comparator
Isolated surgical aortic valve replacement (SAVR)
O
Outcome
Incidence of infective endocarditis (IE) and total mortality in patients with IEhard clinical
Main Result
Relative Risk: 1.09 (95% CI 0.96–1.23)
Absolute Event Rate: 1.86% vs 1.71%
TAVI is associated with a similar risk of infective endocarditis as SAVR, but mortality is significantly higher when endocarditis occurs after TAVI.
Cite This Study
Fauchier et al. (2020) conducted a cohort in Aortic stenosis (n=107,806). Transcatheter aortic valve implantation (TAVI) vs. Isolated surgical aortic valve replacement (SAVR) was evaluated on Incidence of infective endocarditis (RR 1.09, 95% CI 0.96-1.23). Transcatheter aortic valve implantation was associated with a similar risk of infective endocarditis compared to surgical replacement (RR 1.09; 95% CI 0.96-1.23), but higher mortality if it occurred.